منابع مشابه
TGF-β gets primed for action
M yofibroblasts are highly con-tractile cells that repair damaged tissues by secreting and remod-eling the extracellular matrix (ECM) within a wound in order to draw it closed (1). When myofibroblasts are dysregulated, however, they continue to act on healed tissues and induce fi brosis. TGF-1 is a key signaling molecule within the ECM that promotes tissue fi brosis. Klingberg et al. reveal th...
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The pineal hormone melatonin is involved in photic regulations of various kinds, including adaptation to light intensity, daily changes of light and darkness, and seasonal changes of photoperiod lengths. The melatonin effects are mediated by the specific high-affinity receptors localized on plasma membrane and coupled to GTP-binding protein. Two different G proteins coupled to the melatonin rec...
متن کاملMechanisms navigating the TGF-β pathway in prostate cancer
Few pharmacotherapies are currently available to treat castration resistant prostate cancer (CRPC), with low impact on patient survival. Transforming growth factor-β (TGF-β) is a multi-functional peptide with opposite roles in prostate tumorigenesis as an inhibitor in normal growth and early stage disease and a promoter in advanced prostate cancer. Dysregulated TGF-β signaling leads to a cascad...
متن کاملTGF-β and Iron Differently Alter HBV Replication in Human Hepatocytes through TGF-β/BMP Signaling and Cellular MicroRNA Expression
The nature of host-virus interactions in hepatitis B virus infection is incompletely understood. Since soluble factors, e.g., cytokines and metals, may exacerbate liver injury in chronic hepatitis, we considered that defining the effects of receptor-mediated signaling upon viral replication will be significant. Consequently, we studied effects of iron or TGF-β-induced TGF-β/BMP signaling in the...
متن کاملEffect of Transforming Growth Factor-β (TGF-β) on proliferation of gastric epithelial cells in culture
Objective: Helicobacter pylori has a well-established role in the development of gastric cancer. In vitro studies reveal increased proliferation of the gastric mucosa in the presence of H. pylori infection. It has been also shown that production of some cytokines, such as interleukin-1 beta (IL-1b) is in...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1990
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12875031